Proteomics

Dataset Information

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Cellular internalization pathways of environmentally exposed microplastic particles

ABSTRACT: Microplastic particles that occur in the environment are coated with different biomolecules forming an eco-corona on the particles' surface, which could consequently lead to a specific interaction of the constituents of the eco-corona with membrane receptors. To date, it is not fully understood how strong microplastic particles with and without an eco-corona bind to cellular membranes and which underlying mechanisms are responsible for cellular internalization. Here we analyzed the protein composition of two different eco-coronas (freshwater and saltwater) by LC-MS/MS.

INSTRUMENT(S):

ORGANISM(S): Biofilm Metagenome

SUBMITTER: Thomas Fröhlich  

LAB HEAD: Thomas Fröhlich

PROVIDER: PXD050078 | Pride | 2025-03-07

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
FW.raw Raw
FW_nc.raw Raw
SW.raw Raw
SW_nc.raw Raw
Sample_info.txt Txt
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Publications

Cellular internalization pathways of environmentally exposed microplastic particles: Phagocytosis or macropinocytosis?

Ramsperger Anja F R M AFRM   Wieland Simon S   Wilde Magdalena V MV   Fröhlich Thomas T   Kress Holger H   Laforsch Christian C  

Journal of hazardous materials 20250217

Microplastic particles (MP) ubiquitously occur in all environmental compartments where they interact with biomolecules, forming an eco-corona on their surfaces. The eco-corona affects the surface properties of MP and consequently how they interact with cells. Proteins, an integral component within the eco-corona, may serve as a ligand driving the interaction of MP with membrane receptors. To date, it is not known, whether eco-coronae originating from different environmental media differ in their  ...[more]

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