Carrier protein-enabled host cell proteome analysis (CP-HCP) with integrated isobaric tag interference filtering

ABSTRACT: We have created a CP-HCP method to characterise the carrier proteome of a host cell expression system producing recombinant protein biotherapeutic, which can be compared with the testing sample mixture containing trace amounts of host cell proteins against high-background recombinant protein and also a recombinant protein peptide characterisation channel, using TMT labelling.

INSTRUMENT(S):

ORGANISM(S): Escherichia Coli

SUBMITTER: Divyanshi Karmani  

LAB HEAD: Dr John Patrick Murphy

PROVIDER: PXD050214 | Pride | 2026-01-12

REPOSITORIES: Pride