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Characterization of hybrid cells in glioblastoma to better understand the plasticity that could lead to resistance to therapy

ABSTRACT: Cell subtype characterization by comparing cytoplasm and nucleus compartments

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Glioblastoma

SUBMITTER: Vanessa Masson

LAB HEAD: Damarys Loew

PROVIDER: PXD050217 | Pride | 2026-02-23

REPOSITORIES: Pride

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			Action	DRS
	DesignPRIDE.xlsx	Xlsx
	E2294FD.msf	Msf
	E2294FD.raw	Raw
	E2295FD.msf	Msf
	E2295FD.raw	Raw

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Publications

Proneural-mesenchymal hybrid glioblastoma cells are resistant to therapy and dependent on nuclear import.

Bourmeau Guillaume G Anezo Oceane O Raymond Jeremy J Ballestín Alberto A Pichol-Thievend Cathy C Reveilles Juliette J Thomas Adrien A Wang Lin L Miranda Melanie M Moutaux Eve E Liva Stephane S Ribecco Valentino V Besse Laetitia L Dingli Florent F Loew Damarys D Vallot Celine C Gargiulo Gaetano G Ravi Vidhya M VM Joseph Kevin K Seano Giorgio G

Neuro-oncology 20251101 11

<h4>Background</h4>Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have identified various cell states within GBM tumors, the molecular mechanism underlying adaptive GBM cell plasticity induced by conventional therapy remains unclear.<h4>Methods</h4>We used fluorescent reporters for proneural (PN) and mesenchymal (MES) subtypes to monitor GBM cell plasticity in real-time across multiple patient-derived cell lines. Thi ...[more]

PMID: 40627673

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