Proteomics

Dataset Information

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Mast cells modulate macrophage through release of Csf1

ABSTRACT: To systematically identify mast cells-released mediators, we analysed the proteome and secretome of antigen-activated primary mouse mast cells using quantitative mass spectrometry-based proteomics and identified Csf1 as a novel preformed mast cell mediator.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Secretion, Cell Culture, Macrophage Colony-stimulating Factor 1 Receptor (human), Mast Cell Activation Involved In Immune Response

SUBMITTER: Piero Giansanti  

LAB HEAD: Piero Giansanti

PROVIDER: PXD050282 | Pride | 2025-06-23

REPOSITORIES: Pride

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Publications

<h4>Background</h4>Mast cells (MCs) are tissue-resident immune cells present in connective tissues throughout the body. They exert diverse functions in immunity by rapidly releasing a plethora of preformed mediators, including proteoglycans, cytokines, and proteases, which are stored in cytoplasmic granules.<h4>Objective</h4>We sought to systematically and globally identify MC-released protein mediators and elucidate their functions.<h4>Methods</h4>We analyzed the secretomes of antigen-activated  ...[more]

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