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Proteomic analysis of vascular tissue from critical limb ischemia mouse models treated with Etrinabdione

ABSTRACT: Vasculogenic therapies have been investigated for the treatment of peripheral artery disease (PAD) with very limited success in clinical trials. The isoform PP2A (protein phosphatase 2)/B55alpha inhibits the activity of the prolyl hydroxylase 2 (PHD2) and activates the hypoxia inducing factor-1alpha (HIF-1alpha), playing a key role in in vessel remodeling. Thus, PP2A/B55alpha activators may have the potential to induce angiogenesis and arteriogenesis. Herein we investigated the pharmacological attributes of VCE-004.8 (Etrinabdione) and its effectiveness in a murine model of critical limb ischemia.

INSTRUMENT(S): Bruker Daltonics timsTOF series

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Vascular Tissue

DISEASE(S): Peripheral Artery Disease

SUBMITTER: Martin Garrido

LAB HEAD: Eduardo Muñoz

PROVIDER: PXD050360 | Pride | 2024-04-03

REPOSITORIES: Pride

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