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GCN5 interactome in U87MG Control, IR and doxorubicin treated conditions

ABSTRACT: GCN5 interactome in U87MG Control, IR and doxorubicin treated conditions

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Glioblastoma

SUBMITTER: Shilpee Dutt

LAB HEAD: Dr. Shilpee Dutt

PROVIDER: PXD050400 | Pride | 2025-05-13

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	02012020_Fusion_MASSFIITB_Replicate1_Control_GCN5_IP.xlsx	Xlsx
	02012020_Fusion_MASSFIITB_Replicate1_Doxorubicin_GCN5_IP.xlsx	Xlsx
	02012020_Fusion_MASSFIITB_Replicate1_IR_GCN5_IP.xlsx	Xlsx
	29022020_Fusion_MASSFIITB_2068_Replicate2_Control_GCN5_IP.raw	Raw
	29022020_Fusion_MASSFIITB_2068_Replicate2_Control_GCN5_IP.xlsx	Xlsx

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1 - 5 of 21

Publications

PARylation of GCN5 by PARP1 mediates its recruitment to DSBs and facilitates both HR and NHEJ Repair.

Sarkar Debashmita D Chakraborty Amartya A Mandi Shaina S Dutt Shilpee S

Cellular and molecular life sciences : CMLS 20241107 1

Efficient DNA double strand break (DSB) repair is necessary for genomic stability and determines efficacy of DNA damaging cancer therapeutics. Spatiotemporal dynamics and post-translational modifications of repair proteins at DSBs dictate repair efficacy. Here, we identified a non-canonical function of GCN5 in regulating both HR and NHEJ repair post genotoxic stress. Mechanistically, genotoxic stress induced GCN5 recruitment to DSBs. GCN5 PARylation by PARP1 was essential for its recruitment, ac ...[more]

PMID: 39508866

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