Circulating tumour cells shed large extracellular vesicles in capillary-scale bifurcations
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Sara Arfan
LAB HEAD: Dr Paul H Huang
PROVIDER: PXD050444 | Pride | 2025-09-01
REPOSITORIES: Pride
Dataset's files
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| Req293-SA-Huang_V1_rep.raw | Raw | |||
| Req293-SA-Huang_V1_rep.raw.dia.quant | Raw | |||
| Req293-SA-Huang_V2_rep.raw | Raw | |||
| Req293-SA-Huang_V2_rep.raw.dia.quant | Raw | |||
| Req293-SA-Huang_V3_rep.raw | Raw |
Items per page: 5 1 - 5 of 8 |
Publications
Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells.
Vrynas Angelos A Bazban-Shotorbani Salime S Arfan Sara S Satia Karishma K Cunningham Brian B Sagindykova Gauhar G Ashna Mymuna M Zhang Aoyu A Visan Diana D Chen Aisher A Matthews-Palmer Teige T Carter Mathew M Blackhall Fiona F Simpson Kathryn L KL Dive Caroline C Huang Paul P Au Sam H SH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20250609 31
Circulating tumor cells (CTCs) and their clusters are the cellular drivers of metastasis. This study uses microfluidic models mimicking human capillary bifurcations to better understand how these cells interact with capillary beds. Patient CTCs, CTC-derived explant cells, and numerous cancer cell lines shed nuclei-free fragments in a cell size- and bifurcation-dependent manner. These shedding events, which reduces cell sizes up to 61%, facilitate CTC transit through bifurcations. The shed fragme ...[more]
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