Proteomics

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Aeromonas spp MTB Infection May Causally Link to Ulcerative Colitis

ABSTRACT: Ulcerative colitis (UC) is an inflammatory bowel disease characterized by disruption of the epithelial barrier, and its etiology has long been enigmatic. We here observed a significant depletion of macrophages directly beneath the UC epithelial layer, and hypothesized that this depletion may be caused by a toxic bacteria. By screening fecal bacteria of UC patients, we identified the causative bacteria as Aeromonas spp MTB (macrophage-toxic bacteria), a novel variant of Aeromonas genus. The expressed aerolysin was preferentially toxic towards macrophages, and severs as a primary virulent factor. MTB efficiently colonized mice after pretreatment with DSS and antibiotics, and thereby induced UC-like colitis. Moreover, both aerolysin toxin and fecal MTB respectively distributed in UC colon tissue and stool with high frequency. We thus proposed that MTB infection was causally linked to ulcerative colitis. As aerolysin antibody mitigated the colitis phenotypes, our result also revealed an innovative therapeutic approach for UC.

INSTRUMENT(S):

ORGANISM(S): Aeromonas Veronii Bv. Sobria

TISSUE(S): Secretion

SUBMITTER: Zhihui Jiang  

LAB HEAD: Zhu minsheng

PROVIDER: PXD050471 | Pride | 2026-03-17

REPOSITORIES: Pride

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20210831_01.wiff Wiff
20210831_01.wiff.scan Wiff
20210831_01_ZhuMS_1.group Other
20210831_01_ZhuMS_1_MGFPeaklist.mgf Mgf
20210831_01_ZhuMS_1_PeptideSummary.txt Txt
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Publications

Ulcerative colitis (UC) is a severe inflammatory bowel disease affecting millions of people worldwide, but the factors driving the condition are poorly understood. In tissue samples from individuals with UC, we found that macrophages were depleted from areas of the colon that did not yet exhibit overt epithelial inflammation. We hypothesized that toxins produced by bacteria could impair macrophages and that this could promote wider inflammation. We isolated a variant of <i>Aeromonas</i> genus fr  ...[more]

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