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Glyceraldehyde treatment on pancreatic ductal epithelial cells

ABSTRACT: To study the impact of the accumulation of glyceraldehyde-derived intracellular protein advanced glycation end products (AGEs) on global proteomic changes in pancreatic ductal epithelial cells. The cells were treated with glyceraldehyde for up to 2 days and changes of protein expressions were assessed through mass spectroscopic analysis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Disease Free

SUBMITTER: Lakmini Senavirathna

LAB HEAD: Sheng Pan

PROVIDER: PXD050491 | Pride | 2025-07-21

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	HPDE_0mM_1.pep.xml	Pepxml
	HPDE_0mM_1.raw	Raw
	HPDE_0mM_2.pep.xml	Pepxml
	HPDE_0mM_2.raw	Raw
	HPDE_0mM_3.pep.xml	Pepxml

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Publications

Accumulation of Intracellular Protein Advanced Glycation End Products Alters Cellular Homeostasis for Protein Clearance in Pancreatic Ductal Epithelial Cells.

Senavirathna Lakmini L Hasapes Christopher C Chen Ru R Pan Sheng S

Biochemistry 20240628 14

Protein advanced glycation end products (AGEs) can be formed via nonenzymatic glycation and accumulated intracellularly to disrupt cellular homeostasis for protein clearance. Here, we investigated the formation particulars of intracellular protein AGEs and sought to elucidate the molecular events implicated in the impact of cellular clearance systems. The formation and accumulation of intracellular protein AGEs increased protein aggregation and protease resistance, potentially overwhelming the u ...[more]

PMID: 38941592

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