Dataset Information

SERUM PROTEOMICS OF Experimental MALARIA-associated ARDS REVEALS A REGULATION OF ACUTE PHASE RESPONSE PROTEINS

ABSTRACT: Malaria is a parasitic infectious disease considered a public health problem. Acute respiratory distress syndrome (ARDS) is a complication in malaria-infected individuals with a high mortality rate (80% to 100%) and can occur before, during, or after antimalarial drug treatment. Although inflammation and epithelial/endothelial injuries pathways have been determined through these studies, specific circulating malaria-associated ARDS markers have not yet been established. We applied a quantitative mass spectrometry-based proteomic approach to identify altered molecular pathways in a mouse model of malaria-associated ARDS. Acute phase response proteins were regulated in the ARDS group, suggesting potential progression biomarkers.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Serum

SUBMITTER: Simon Mule

LAB HEAD: Prof. Dr. Giuseppe Palmisano

PROVIDER: PXD050496 | Pride | 2025-05-13

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	Serum_LR_ARDS_DD.xlsx	Xlsx
	Serum_LR_ARDS_DTT.xlsx	Xlsx
	Serum_LR_ARDS_TCA.xlsx	Xlsx
	Velos0420_LR_ARDS_DD_03.raw	Raw
	Velos0420_LR_ARDS_DD_04.raw	Raw

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Publications

Serum Proteomics of Experimental Malaria-Associated ARDS Reveals a Regulation of Acute-Phase Response Proteins.

Rosa-Fernandes Lívia L Santiago Verônica Feijoli VF da Silva-Santos Yasmin Y Lopes Tissiane Tarosso TT Peixoto Erika Paula Machado EPM Rodrigues Stefani Aparecida Minchio SAM Marinho Claudio Romero Farias CRF Palmisano Giuseppe G Epiphanio Sabrina S

Journal of immunology research 20250323

Malaria is a parasitic infectious disease considered a public health problem. Acute respiratory distress syndrome (ARDS) is a complication in malaria-infected individuals with a high mortality rate (80% to 100%) and can occur before, during, or after antimalarial drug treatment. Although inflammation and epithelial/endothelial injury pathways have been determined through these studies, specific circulating malaria-associated ARDS markers have not yet been established. We applied a quantitative m ...[more]

PMID: 40160901

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