Effect of a probiotic goat milk on the hepatic proteomic profile of mice fed a high-fat diet

ABSTRACT: Fermented goat milk (FGM) with Lactobacillus delbrueckii subsp. indicus CRL1447 and supplemented with different mixes of lactobacilli strains (Mix1: Limosilactobacillus fermentum CRL1446 + Lactiplantibacillus paraplantarum CRL1449 + Lactiplantibacillus paraplantarum CRL1472; Mix2: CRL1446 + CRL1449; Mix3: CRL1446 + CRL1472; and Mix4: CRL1449 + CRL1472) was administered to mice fed a high-fat diet. Proteomics data show that high-fat diet generally upregulates proteins involved in fatty acid oxidation and downregulates proteins taking part in lipid synthesis, whereas the administration of FGM+Mix3 positively modulates the hepatic proteomic profile.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Enterococcus Faecalis (streptococcus Faecalis) Heliocidaris Erythrogramma (sea Urchin) Bombyx Mori (silk Moth) Candida Albicans (yeast) Brassica Oleracea Var. Botrytis (cauliflower) Helicobacter Pylori J99 (campylobacter Pylori J99) Merluccius Bilinearis (silver Hake) Halobacterium Salinarum Drosophila Melanogaster (fruit Fly) Hepatitis C Virus Subtype 1a Escherichia Coli Ictalurus Punctatus (channel Catfish) Hordeum Vulgare (barley) Brassica Napus (rape) Dictyostelium Discoideum (slime Mold) Gadus Morhua (atlantic Cod) Olea Europaea (common Olive) Equus Caballus (horse) Caenorhabditis Elegans Danio Rerio (zebrafish) (brachydanio Rerio) Macaca Mulatta (rhesus Macaque) Arachis Hypogaea (peanut) Mesocricetus Auratus (golden Hamster) Nicotiana Tabacum (common Tobacco) Cercopithecus Aethiops (green Monkey) (grivet) Homo Sapiens (human) Bos Taurus (bovine) Gallus Gallus (chicken) Cicer Arietinum (chickpea) (garbanzo) Mus Musculus (mouse)

TISSUE(S): Heart, Brain, Flower, Embryo, Cell Suspension Culture, Cotyledon, Egg, Liver, Cerebrospinal Fluid, Flower Bud, Kidney, Hela Cell, Erythrocyte, Dendritic Cell, Cell Culture, Leaf, Endosperm, Colon, Bone Marrow, Jurkat Cell

SUBMITTER: María Antonela Marquez  

LAB HEAD: Paola Gauffin-Cano

PROVIDER: PXD050536 | Pride | 2025-06-05

REPOSITORIES: Pride