Dataset Information
GLS1 interactome in liver cells by IP followed by LC-MS/MS
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hepatocyte, Cell Culture
DISEASE(S): Disease Free
SUBMITTER: 
wenbiao wu
LAB HEAD: wenbiao wu
PROVIDER: PXD050603 | Pride | 2025-12-08
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Ei15JHW_GAC.raw | Raw | |||
| Ei15JHW_KGA.raw | Raw | |||
| peptide.csv | Csv | |||
| protein-peptides.csv | Csv | |||
| proteins.csv | Csv |
Items per page: 1 - 5 of 5 |
Publications
GLS1-RNA Polymerase II Axis Mediates Glutamine-Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High-Protein Diets.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20250911 45
The RNA polymerase II (RNA pol II) complex is essential for gene transcription throughout life, and numerous cofactors have been identified as critical for diverse transcriptional processes. Herein, it is discovered that the RNA pol II complex is modulated by glutaminase 1 (GLS1), which affects lipid metabolism. In alcoholic fatty liver disease (AFLD), RNA pol II activation is observed, whereas RNA pol II inhibition reverse hepatic steatosis. Furthermore, high-protein diets are recognized for th ...[more]