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Quantitative proteomics identifies conserved proteins and altered regulation of mucin-16 in low grade serous ovarian cancers.

ABSTRACT: Low-grade serous ovarian carcinoma (LGSOC) is a rare and largely chemoresistant subtype of epithelial ovarian cancer. Unlike treatment for high-grade serous ovarian cancer (HGSOC), management options for LGSOC patients are limited, in part, due to a lack of deep molecular characterization of this disease. To address this limitation, we aimed to define highly conserved proteome alterations in LGSOC by performing deep quantitative proteomic analysis of tumors collected from LGSOC and HGSOC patients or normal fallopian tube tissues and validating proteins within two independent proteomic datasets of LGSOC and HGSOC tumors.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Oviduct Epithelium, Ovarian Epithelial Cell

DISEASE(S): Ovarian Serous Carcinoma

SUBMITTER: Thomas Conrads

LAB HEAD: Thomas P.

PROVIDER: PXD050642 | Pride | 2025-09-30

REPOSITORIES: Pride

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			Action	DRS
	Fallopian_Sample_Reference_File.xlsx	Xlsx
	Fallopian_TMT11_QEHFX1_11_01.raw	Raw
	Fallopian_TMT11_QEHFX1_11_02.raw	Raw
	Fallopian_TMT11_QEHFX1_11_03.raw	Raw
	Fallopian_TMT11_QEHFX1_11_04.raw	Raw

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