Binding partners of BAG3 in human iPS-cardiac fibroblasts.
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Rajesh Soni
LAB HEAD: Gordana Vunjak-Novakovic
PROVIDER: PXD050740 | Pride | 2025-05-06
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| BW1182_BAG3.zip | Other | |||
| BW1182_ProteinGroups.xlsx | Xlsx |
Items per page: 5 1 - 2 of 2 |
Publications
Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy.
Wang Bryan Z BZ Morsink Margaretha Aj MA Kim Seong Won SW Luo Lori J LJ Zhang Xiaokan X Soni Rajesh Kumar RK Lock Roberta I RI Rao Jenny J Kim Youngbin Y Zhang Anran A Neyazi Meraj M Gorham Joshua M JM Kim Yuri Y Brown Kemar K DeLaughter Daniel M DM Zhang Qi Q McDonough Barbara B Watkins Josephine M JM Cunningham Katherine M KM Oudit Gavin Y GY Fine Barry M BM Seidman Christine E CE Seidman Jonathan G JG Vunjak-Novakovic Gordana G
The Journal of clinical investigation 20250102 1
Loss of Bcl2-associated athanogene 3 (BAG3) is associated with dilated cardiomyopathy (DCM). BAG3 regulates sarcomere protein turnover in cardiomyocytes; however, the function of BAG3 in other cardiac cell types is understudied. In this study, we used an isogenic pair of BAG3-knockout and wild-type human induced pluripotent stem cells (hiPSCs) to interrogate the role of BAG3 in hiPSC-derived cardiac fibroblasts (CFs). Analysis of cell type-specific conditional knockout engineered heart tissues r ...[more]
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