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Lysyl Oxidase Mediated Collagen Cross-linking in Pancreatic Cancer

ABSTRACT: Bottom up proteomics, cross-linked amino acid analysis, and cross-linked peptide analysis were performed on eight PDAC tumor samples and paired adjacent non-tumor samples.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Pancreas

DISEASE(S): Pancreatic Ductal Adenocarcinoma

SUBMITTER: Kirk Hansen

LAB HEAD: Kirk Hansen

PROVIDER: PXD050833 | Pride | 2025-08-28

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	Cell_combined.pep.xml	Pepxml
	PDAC_File_Key_Experimental_Conditions.xlsx	Xlsx
	QEHF_20171004_NormalPanc_SCX_Pool0.raw	Raw
	QEHF_20171004_NormalPanc_SCX_Pool1.raw	Raw
	QEHF_20171004_NormalPanc_SCX_Pool2.raw	Raw

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Publications

Pancreatic Cancer Progression Involves Increased Lysyl Oxidase-Mediated Collagen Cross-Links as Part of the Desmoplastic Reaction.

Barrett Alex A Maslanka Mark D MD Darula Zsuzsanna Z McCabe Maxwell C MC Saviola Anthony J AJ Schmitt Lauren R LR Weaver Valerie V Pitts Todd M TM Messersmith Wells A WA Hansen Kirk C KC

Biochemistry 20250808 16

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal disease characterized by extensive extracellular matrix (ECM) remodeling and fibrosis. In general, the formation of a desmoplastic stroma is associated with dynamic ECM remodeling and resistance to most standard-of-care treatments, such as conventional chemotherapy. Here, we report on alterations to core ECM and ECM remodeling enzymes, which include significant changes in levels of lysyl hydroxylase and oxidase enzymes tha ...[more]

PMID: 40778924

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