Enhancing CAR T-cell efficacy against neuroblastoma through MIF inhibition

ABSTRACT: Neuroblastoma is a common pediatric extracranial solid tumor, that arises in the developing sympathetic nervous system. Chimeric antigen receptor (CAR) T-cell therapy has demonstrated promising clinical responses, yet its effectiveness in neuroblastoma benefits only a subset of patients. We evaluated the immunosuppressive secretome of neuroblastoma tumoroids that attenuate CAR T-cells function and efficacy. Secreted proteins were collected from tumoroids and identified by shotgun MS.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Neuroblastoma Cell

DISEASE(S): Neuroblastoma

SUBMITTER: Elisavet Kalaitsidou  

LAB HEAD: wei wu

PROVIDER: PXD051044 | Pride | 2025-04-02

REPOSITORIES: Pride