Dataset Information

Mass spectrometry of neuroblastoma organoids

ABSTRACT: Collect proteomic data for organoids from relapsed neuroblastoma patients

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Peter Hains

LAB HEAD: Phillip Robinson

PROVIDER: PXD051208 | Pride | 2025-05-06

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20240403_iPC.csv	Csv
	20240410_Organoid_protein_DIA-NN_Search.csv	Csv
	211007_B1-1-T1-1_01YKU_0212F_M01_S_1.wiff	Wiff
	211007_B1-1-T1-1_01YKU_0212F_M01_S_1.wiff.scan	Wiff
	211007_B1-10-T1-1_01YLL_0212O_M01_S_1.wiff	Wiff

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Publications

Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma.

Strijker Josephine G M JGM Pascual-Pasto Guillem G Grothusen Grant P GP Kalmeijer Yannine J YJ Kalaitsidou Elisavet E Zhao Chunlong C McIntyre Brendan B Matlaga Stephanie S Visser Lindy L LL Barisa Marta M Himsworth Courtney C Shah Rivani R Muller Henrike H Schild Linda G LG Hains Peter G PG Zhong Qing Q Reddel Roger R RR Robinson Phillip J PJ Catena Xavier X Soengas María S MS Margaritis Thanasis T Dekker Frank J FJ Anderson John J Molenaar Jan J JJ Bosse Kristopher R KR Wu Wei W Wienke Judith J

European journal of cancer (Oxford, England : 1990) 20250127

<h4>Introduction</h4>Chimeric antigen receptor (CAR) T-cell therapy is a promising and innovative cancer therapy. However, immunosuppressive tumor microenvironments (TME) limit T cell persistence and durable efficacy. Here, we aimed to identify and target immunosuppressive factors in the TME of neuroblastoma, a pediatric extracranial solid tumor, to improve CAR-T efficacy.<h4>Methods</h4>Immunosuppressive factors were identified using a multi-omics approach, including single-cell RNA sequencing ...[more]

PMID: 39908652

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