Proteomics

Dataset Information

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Placenta-derived Extracellular Vesicles in Maternal Plasma of Hb Bart’s Fetuses

ABSTRACT: Our study has demonstrated a profile of extracellular vesicle (EVs) in women with Hb Bart’s fetalis fetuses. Specifically, women with Bart’s fetuses have smaller EVs particle size but higher placental alkaline phosphatase (PLAP)-EV level than those with normal pregnancies. Several proteomics EV proteins are differentially expressed in women with Bart’s fetuses and these proteins involves in zymogen activation, fibrinogen complex, vesicles in cellular component, fibrin clot formation and integrin signaling. We envision that the non-invasive liquid biopsy could provide information in relation to placental health in women with Bart’s fetuses. In this report, the liquid biopsy based on an examination of placenta-derived EVs in maternal blood for the identification of Hb Bart’s fetuses is feasible and this may ultimately reduce the rate of unnecessary invasive prenatal diagnosis testing inthe future.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebrospinal Fluid

SUBMITTER: PUNTABUT WARINTAKSA  

LAB HEAD: Dr Wararat Chiangjong

PROVIDER: PXD051236 | Pride | 2025-12-01

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
All_3_gr_add_PLAP.group Other
Bart20_IDA1.mzXML Mzxml
Bart20_IDA1.wiff Wiff
Bart20_IDA1.wiff.scan Wiff
Bart20_IDA2.mzXML Mzxml
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Publications

Hemoglobin (Hb) Bart's disease is the most common cause of hydrops fetalis among Southeast Asians. Given its high fatality rate, prenatal diagnosis and treatment are the key. This condition is associated with placental hypoxia, which can trigger the release of placenta-derived extracellular vesicles (EVs) into the maternal circulation. We aimed to determine the levels of placenta-derived EVs and the proteomic profiles of plasma EVs in women with fetuses with Hb Bart. This prospective cohort stud  ...[more]

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