Dataset Information

NLRC5 IP-MS in neonatal mouse cardiomyocyte lysates

ABSTRACT: The neonatal mouse cardiomyocytes (NMCMs) lysate was immunoprecipitated using either IgG (control) or anti-NLRC5 antibody. Immunoprecipitated samples were subjected to SDS-PAGE followed by high-throughput LC/MS to identify the candidate interacting proteins of NLRC5.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Lingfeng Gu

LAB HEAD: Lingfeng Gu

PROVIDER: PXD051371 | Pride | 2025-05-06

REPOSITORIES: Pride

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Publications

Targeting NLRC5 in cardiomyocytes protects postinfarction cardiac injury by enhancing autophagy flux through the CAVIN1/CAV1 axis.

Gu Lingfeng L Wang Sibo S Zhou Liuhua L Wang Wenjing W Bao Yulin Y He Ye Y Yang Tongtong T Sun Jiateng J Jiang Qiqi Q Shan Tiankai T Du Chong C Wang Zemu Z Wang Hao H Xie Liping L Gu Aihua A Zhao Yang Y Ji Yong Y Wang Qiming Q Wang Liansheng L

Communications biology 20250223 1

NOD-like receptor (NLR) family proteins are implicated in various cardiovascular diseases. However, the precise role of NLRC5, the largest member of this family, in myocardial infarction (MI) remains poorly understood. This study reveals that NLRC5 is upregulated in the hearts of both patients with MI and MI mice. Silencing NLRC5 in cardiomyocytes impairs cardiac repair and functional recovery, while its overexpression enhances these processes. Furthermore, NLRC5 promotes autophagy in cardiomyoc ...[more]

PMID: 39988583

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			Action	DRS
	77773-NC_IgG.pdResult	Other
	77773-NC_IgG.raw	Raw
	77773-NC_NLRC5.pdResult	Other
	77773-NC_NLRC5.raw	Raw
	77773-OE_IgG.pdResult	Other