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Identification of PARP15 enzymatic substrates

ABSTRACT: Recombinant JNK-interacting protein 3 (JIP3) was incubated with enzymatically active PARP15 and biotinylated NAD to determine residues modified by mono-ADP ribosylation (MAR)

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Capillary Leak Syndrome

SUBMITTER: Kirk Druey

LAB HEAD: Kirk Druey

PROVIDER: PXD051413 | Pride | 2025-12-08

REPOSITORIES: Pride

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			Action	DRS
	PI21-25093-L1.raw	Raw
	PI21-25093-L1.raw_20240404_Byonic.mgf	Mgf
	PI21-25093-L1.raw_20240404_Byonic.mzid.gz	Mzid
	PI21-25093-L2-cs1.raw	Raw
	PI21-25093-L2-cs1.raw_20240404_Byonic.mgf	Mgf

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Publications

<i>PARP15</i> Is a Susceptibility Locus for Clarkson Disease (Monoclonal Gammopathy-Associated Systemic Capillary Leak Syndrome).

Chan Eunice C EC Ablooglu Ararat J AJ Ghosh Chandra C CC Desai Abhishek A Schaible Niccole N Chen Xiuying X Zhao Ming M Olano M Renee MR Ganesan Sundar S Lack Justin B JB Krishnan Ramaswamy R Parikh Samir M SM Druey Kirk M KM

Arteriosclerosis, thrombosis, and vascular biology 20241031 12

<h4>Background</h4>Vascular leakage is a deadly complication of severe infections, ranging from bacterial sepsis to malaria. Worldwide, septicemia is among the top 10 causes of lethality because of the shock and multiorgan dysfunction that arise from the host vascular response. In the monoclonal gammopathy-associated capillary leak syndrome (MG-CLS), even otherwise mundane infections induce recurrent septic-like episodes of profound microvascular hyperpermeability and shock. There are no defined ...[more]

PMID: 39479769

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Protein ADP-ribosylation, phosphorylation, and interactome dynamics in macrophage activation.

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2020-06-17 | PXD016469 | Pride

Mutational screens highlight glycosylation as a modulator of colony-stimulating factor 3 receptor (CSF3R) activity

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Label-Free Quantification Method for Assessing Sex from Modern and Ancient Bovine Tooth Enamel PART II

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