SILAC experiment quantifying the proteomics of WT and HBO1-KO HeLa

ABSTRACT: Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. We report that HBO1 functions as a lysine lactyltransferase to regulate transcription. Quantitative proteomic analysis further revealsed 95 endogenous Kla sites targeted by HBO1, with the majority located on histones.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Cervix Squamous Epithelium

DISEASE(S): Cervix Carcinoma

SUBMITTER: siyu wang  

LAB HEAD: Kai Zhang

PROVIDER: PXD051415 | Pride | 2024-04-13

REPOSITORIES: Pride