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TMT proteomic analysis of HBV-infected vs non-infected HepG2-NTCP cell line

ABSTRACT: Deep-scale proteomic study on HBV-infected vs non-infected HepG2-NTCP cell line was conductedat day2 and day10 post-infection. Urea lysis buffer was used. This allows to identify the signaling pathways and proteins which result to be dysregulated during chronic HBV infection.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Hepatitis B Virus

TISSUE(S): Hepatocyte

SUBMITTER: Alessia Virzi

LAB HEAD: Joachim Lupberger

PROVIDER: PXD051443 | Pride | 2025-07-21

REPOSITORIES: Pride

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			Action	DRS
	Beaker_20190524_OP_HStmt_Lupberger_Proteome_fr1.raw	Raw
	Beaker_20190524_OP_HStmt_Lupberger_Proteome_fr10.raw	Raw
	Beaker_20190524_OP_HStmt_Lupberger_Proteome_fr11.raw	Raw
	Beaker_20190524_OP_HStmt_Lupberger_Proteome_fr12.raw	Raw
	Beaker_20190524_OP_HStmt_Lupberger_Proteome_fr13.raw	Raw

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Publications

Hepatitis B virus-infected hepatocytes promote the secretion of collagen VI to the extracellular matrix.

Virzì Alessia A Boulahtouf Zakaria Z Moehlin Julien J Girard Lea L Meiss-Heydmann Laura L Bach Charlotte C Gerges Emma E Durand Sarah C SC Oudot Marine A MA Roca Suarez Armando A AA Popp Oliver O Ramberger Evelyn E Mertins Philipp P Felli Emanuele E Pessaux Patrick P Schuster Catherine C Verrier Eloi R ER Baumert Thomas F TF Lupberger Joachim J

Scientific reports 20250710 1

Chronic hepatitis B virus (HBV) infection is a global health problem as it is the major cause of liver fibrosis and its complications cirrhosis and hepatocellular carcinoma. The role of virus-host interactions in liver fibrosis and progression to cancer remains poorly understood. Here we show that HBV infection of permissive cells trigger pathways relevant for extracellular matrix (ECM) remodeling, which is a hallmark of liver fibrosis. We demonstrate that collagen VI (ColVI) is secreted from in ...[more]

PMID: 40640389

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