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Breast tissue and cancer proteomics

ABSTRACT: Breast tissue sample from the Koman tissue bank and UW Oncology. Proteomic analysis of non-cancer tissue by BMI catagory.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Mammary Gland

DISEASE(S): Breast Cancer

SUBMITTER: Kirk Hansen

LAB HEAD: Kirk Hansen

PROVIDER: PXD051458 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	20240329_180335_20190711_Conklin_Cell_base.sne	Other
	20240330_101437_20190725_Conklin_ECM_base.sne	Other
	QEHF_20190711_Conklin_Cell_DIA_Sample01.raw	Raw
	QEHF_20190711_Conklin_Cell_DIA_Sample02.raw	Raw
	QEHF_20190711_Conklin_Cell_DIA_Sample03.raw	Raw

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Publications

Obesity-driven changes in breast tissue exhibit a pro-angiogenic extracellular matrix signature.

Bamberg Ellen E EE Maslanka Mark M Vinod-Paul Kiran K Sams Sharon S Pollack Erica E Conklin Matthew M Kabos Peter P Hansen Kirk C KC

Matrix biology plus 20240922

Obesity has reached epidemic proportions in the United States, emerging as a risk factor for the onset of breast cancer and a harbinger of unfavorable outcomes [1], [2], [3]. Despite limited understanding of the precise mechanisms, both obesity and breast cancer are associated with extracellular matrix (ECM) rewiring [4], [5], [6]. Utilizing total breast tissue proteomics, we analyzed normal-weight (18.5 to < 25 kg/m<sup>2</sup>), overweight (25 to < 30 kg/m<sup>2</sup>), and obese (≥30 kg/m<sup ...[more]

PMID: 39380725

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Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment

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