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A novel system for 3D co-culture hair follicle mimetic tissue

ABSTRACT: Our study developed a novel 3D co-culture system to mimic the in vivo ECM dynamics. Using this system, we examined the interaction between primary dermal papilla cells isolated from patients with neonatal keratinocytes.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hair Follicle Dermal Papilla Cell

SUBMITTER: Hung Vu

LAB HEAD: HEUNG SIK HAHM

PROVIDER: PXD051461 | Pride | 2025-05-06

REPOSITORIES: Pride

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			Action	DRS
	240403_Aju_TMT_F1.pepXML	Pepxml
	240403_Aju_TMT_F1.raw	Raw
	240403_Aju_TMT_F10.pepXML	Pepxml
	240403_Aju_TMT_F10.raw	Raw
	240403_Aju_TMT_F11.pepXML	Pepxml

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Publications

High-Throughput Screening of 3-Dimensional Co-culture Hair Follicle Mimetic Tissue with an Enhanced Extracellular Matrix for the Screening of Hair Growth-Promoting Compounds.

Pham Huyen T M HTM Kim Hyo-Sop HS Nguyen Duc Long DL Joo Hyun Woo HW Kim Min Kyu MK Sung Young Kwan YK Vu Minh Hung MH Hahm Heung Sik HS Kim Woo Jung WJ Kim Jae-Ho JH Park Hyun-Ji HJ

Biomaterials research 20241227

Hair follicle cells reside within a complex extracellular matrix (ECM) environment in vivo, where physical and chemical cues regulate their behavior. The ECM is crucial for hair follicle development and regeneration, particularly through epithelial-mesenchymal interactions. Current in vitro models often fail to replicate this complexity, leading to inconsistencies in evaluating hair loss treatments. Advanced 3-dimensional (3D) culture systems that better mimic in vivo ECM dynamics are needed for ...[more]

PMID: 39735728

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