Dataset Information

Blood-brain barrier dysfunction in brain metastasis formation in HER2-positive breast cancer

ABSTRACT: we investigated the role of bioactive molecules secreted by HER2+ BC cells in BBB dysfunction during the formation of the pre-metastatic niche before the onset of BrM. We demonstrate that systemic signaling derived from brain metastatic HER2+ primary tumors instigates BBB dysfunction

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Culture Fluid, Epithelial Cell

DISEASE(S): Breast Cancer

SUBMITTER: Ana Sofia Ribeiro

LAB HEAD: Célia Gomes

PROVIDER: PXD051579 | Pride | 2025-05-06

REPOSITORIES: Pride

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Publications

ENPP1 induces blood-brain barrier dysfunction and promotes brain metastasis formation in human epidermal growth factor receptor 2-positive breast cancer.

Santos Liliana L Tomatis Francesca F Ferreira Hugo R S HRS Almeida Sara F F SFF Ciputra Edward E Sereno José J Almeida Rui R Teixeira Paulo P Ribeiro Ana Sofia AS Moreira João N JN Silva Ana P AP Ferreira Lino L Abrunhosa Antero J AJ Gomes Célia M CM

Neuro-oncology 20250101 1

<h4>Background</h4>Brain metastasis (BrM) is a devastating end-stage neurological complication that occurs in up to 50% of human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) patients. Understanding how disseminating tumor cells manage to cross the blood-brain barrier (BBB) is essential for developing effective preventive strategies. We identified the ecto-nucleotidase ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) as specifically enriched in the secretome of ...[more]

PMID: 39210244

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			Action	DRS
	Brain_JIMT1.pdResult	Other
	Brain_SUM190.pdResult	Other
	JIMP1_P_R2.raw	Raw
	JIMT1_BR_R1.raw	Raw
	JIMT1_BR_R2.raw	Raw