Blood-brain barrier dysfunction in brain metastasis formation in HER2-positive breast cancer

ABSTRACT: we investigated the role of bioactive molecules secreted by HER2+ BC cells in BBB dysfunction during the formation of the pre-metastatic niche before the onset of BrM. We demonstrate that systemic signaling derived from brain metastatic HER2+ primary tumors instigates BBB dysfunction

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Culture Fluid, Epithelial Cell

DISEASE(S): Breast Cancer

SUBMITTER: Ana Sofia Ribeiro  

LAB HEAD: Célia Gomes

PROVIDER: PXD051579 | Pride | 2025-05-06

REPOSITORIES: Pride