SILAC based quantitative 3-hydroxybutyromics of HBO1-WT and HBO1-KO HeLa cells

ABSTRACT: Ketogenesis derived BHB facilitates 3-hydroxybutyrylation on lysine linking metabolism with epigenetic regulation. Herein, we found HBO1 served as 3-hydroxybutyryltransferase preferentially catalyzing lysine 9 of histone H3 (H3K9bhb). Moreover, total 1171 Kbhb sites on 582 proteins were identified. Collectively, we firstly descibed HBO1 mediated Kbhb regulatory network in HeLa cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell Of Cervix, Hela Cell

DISEASE(S): Cervical Cancer

SUBMITTER: siyu wang  

LAB HEAD: Kai Zhang

PROVIDER: PXD051668 | Pride | 2025-07-04

REPOSITORIES: Pride