Dataset Information

Human triple negative breast cancer cell line MDA-MB-231 LC-MSMS

ABSTRACT: To detect the protein that interact with NONO and illustrate the important role and the biological mechanism it may involved of NONO in TNBC.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Li Qixiang

LAB HEAD: Quan Zhao

PROVIDER: PXD051842 | Pride | 2025-05-06

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	NONO-BioID2.raw	Raw
	Result-NONO.xlsx	Xlsx

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Publications

NONO interacts with nuclear PKM2 and directs histone H3 phosphorylation to promote triple-negative breast cancer metastasis.

Li Qixiang Q Ci Hongfei H Zhao Pengpeng P Yang Dongjun D Zou Yi Y Chen Panhai P Wu Dongliang D Shangguan Wenbing W Li Wenyang W Meng Xingjun X Xing Mengying M Chen Yuzhong Y Zhang Ming M Chen Bing B Kong Lingdong L Zen Ke K Huang David C S DCS Jiang Zhi-Wei ZW Zhao Quan Q

Journal of experimental & clinical cancer research : CR 20250310 1

<h4>Background</h4>Emerging evidence has revealed that PKM2 has oncogenic functions independent of its canonical pyruvate kinase activity, serving as a protein kinase that regulates gene expression. However, the mechanism by which PKM2, as a histone kinase, regulates the transcription of genes involved in triple-negative breast cancer (TNBC) metastasis remains poorly understood.<h4>Methods</h4>We integrated cellular analysis, including cell viability, proliferation, colony formation, and migrati ...[more]

PMID: 40059196

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