Proteomics

Dataset Information

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Plasma proteomics of Multisystem Inflammatory Syndrome in Children

ABSTRACT: Multisystem inflammatory syndrome in Children (MIS-C) occurs in children between two and six weeks following an initial SARS-CoV-2 infection. The mechanism through which a minority of children develop the hyperinflammation characteristic of MIS-C, while others remain well, is unknown. In this study we present an in-depth assessment of the proteome of children before and after SARS-CoV-2 infection, including children with MIS-C. Reassuringly, these data show that there were minimal changes to the circulating proteome in healthy children as result of SARS-CoV2 infection and there was no evidence of continued inflammation following SARS-CoV-2 infection in children. However, activation of pro-inflammatory pathways and raised circulating markers of myocardial and vascular damage were found to be significantly associated with MIS-C. Our findings have been verified in silico using publicly available proteomic datasets and hence several promising candidate biomarker proteins for diagnosis of MIS-C are identified and described herein.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Multisystem Inflammatory Syndrome In Children

SUBMITTER: Cathal Roarty  

LAB HEAD: Chris Watson

PROVIDER: PXD051939 | Pride | 2025-08-25

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
2022_07_11_QUB_Rapid_19_DIA_1A10_S1-A11_1_5765.d_1_analysis.tdf Other
2022_07_11_QUB_Rapid_19_DIA_1A11_S1-A12_1_5766.d_2_analysis.tdf Other
2022_07_11_QUB_Rapid_19_DIA_1A12_S1-B1_1_5767.d_3_analysis.tdf Other
2022_07_11_QUB_Rapid_19_DIA_1A1_SR_S1-A2_1_5756.d_4_analysis.tdf Other
2022_07_11_QUB_Rapid_19_DIA_1A2_S1-A3_1_5757.d_5_analysis.tdf Other
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Publications

In depth characterisation of the proteome of MIS-C and post COVID-19 infection in children reveals inflammatory pathway activation and evidence of tissue damage.

Roarty Cathal C   Tonry Claire C   McGinn Claire C   Christie Sharon S   Waterfield Tom T   Watson Chris C  

Journal of translational medicine 20250818 1

<h4>Background</h4>Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe complication that arises between two and six weeks after initial SARS-CoV-2 infection. The mechanisms underlying why only a subset of children develop this hyperinflammatory response remain unclear.<h4>Methods</h4>We performed an in-depth proteomic analysis of plasma samples from children before and after SARS-CoV-2 infection, including those who developed MIS-C. Proteomic profiling was conducted using  ...[more]

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