Proteomics

Dataset Information

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Deficiency of Antioxidant Enzyme PRDX6 and Mucosal Chemokine CXCL17: Unraveling the Factors Behind Oxidative Stress and Mucosal Homeostasis Disruption in Dry Eye Disease


ABSTRACT: This study aimed to identify dysregulated proteins, signaling pathways, and biological processes on the ocular surface of patients with Sjögren’s syndrome dry eye (SSDE) disease. Non-targeted proteomic analysis of Schirmer strip (ScS) samples from 12 SSDE patients compared to 6 healthy subjects (HS) revealed 111 dysregulated proteins. It showed significant proteome segregation between SSDE patients and HS, revealing alterations in the cytoskeleton, cell junctions, and cellular metabolism, as well as increased apoptosis and oxidative stress and reduced levels of CXCL17 and PRDX6 in SSDE.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Tear

DISEASE(S): Sjogren's Syndrome

SUBMITTER: Cédric Pionneau  

LAB HEAD: Karima KESSAL

PROVIDER: PXD051945 | Pride | 2025-07-25

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MaxQuant_txt_folder.zip Other
TIMSIDE_LCMS04_HS-1_Slot1-28_1_2603.apl Other
TIMSIDE_LCMS04_HS-1_Slot1-28_1_2603.d.zip Other
TIMSIDE_LCMS04_HS-2_Slot1-29_1_2577.apl Other
TIMSIDE_LCMS04_HS-2_Slot1-29_1_2577.d.zip Other
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