Effect of Mavacamten on skeletal muscle fibre proteome in nemaline myopathy

ABSTRACT: Nemaline myopathy (NM) is a genetic muscle disorder, notably caused by mutations in the NEB gene (NEB-NM). Here we investigated the efficacy of a four-week Mavacamten (myosin ATPase inhibitor) treatment using a NEB-NM mouse model. After the four weeks, soleus muscles were extracted, muscle fibres were isolated, and a global untargeted proteomics approach was employed. As presented in the data set, a lot of various proteins were affected by the treatment.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skeletal Muscle Fiber, Skeletal Muscle Cell

SUBMITTER: Michael Wierer  

LAB HEAD: Julien Ochala

PROVIDER: PXD051963 | Pride | 2025-10-14

REPOSITORIES: Pride