Proteomics

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Proteomic Analysis of Carotid Artery Plaques With and Without Vulnerable Features on Magnetic Resonance Angiography with Vessel Wall Imaging: A Pilot Study


ABSTRACT: Single-center, cohort study of plaques identified with and without vulnerable features on magnetic resonance angiography with vessel wall imaging. Proteomic analysis of these plaques demonstrates different protein composition. These proteins may be used for early detection and intervention or as pharmacologic targets in patients with higher risk for stroke carotid artery disease.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Carotid Artery

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Benjamin Madden  

LAB HEAD: Young Erben

PROVIDER: PXD052120 | Pride | 2025-05-07

REPOSITORIES: Pride

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Proteomic analysis of carotid artery plaques with and without vulnerable features on magnetic resonance angiography with vessel wall imaging: a pilot study.

Madden Benjamin J BJ   Polania-Sandoval Camilo C   Pujari Ganesh P GP   Mangalaparthi Kiran K KK   Charlesworth M Cristine MC   Prudencio Mercedes M   Gendron Tania T   Sandhu Sukhwinder J S SJS   Nassar Aziza A   Petrucelli Leonard L   Meschia James F JF   Pandey Akhilesh A   Erben Young Y  

JVS-vascular science 20250121


<h4>Objective</h4>Extracranial carotid artery pathology accounts for 15% to 20% of ischemic strokes. Advancements in magnetic resonance angiography (MRA) with vessel wall imaging (VWI) have enabled the identification of vulnerable plaques, aiding in risk stratification for neurovascular events. This pilot study aimed to identify proteins in plaques with and without vulnerable features on MRA with VWI.<h4>Methods</h4>Consecutive patients undergoing carotid endarterectomy were included in the stud  ...[more]

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