Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Hepatocyte, Cell Culture
DISEASE(S): Type 2 Diabetes Mellitus
SUBMITTER: Shanshan Li
LAB HEAD: Cheng Hu
PROVIDER: PXD052214 | Pride | 2025-05-07
REPOSITORIES: Pride
Action | DRS | |||
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RD174GP_Dyrk1b-KO.raw | Raw | |||
RD174GP_Flox.raw | Raw | |||
RD174GP_search_data.zip | Other | |||
checksum.txt | Txt |
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Nucleic acids research 20250401 8
Dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B), a member of the CMGC group of kinases, is linked to metabolic syndrome, though the underlying molecular mechanisms remain unclear. In this study, we show that Dyrk1b expression is induced in the liver by fasting and in diabetic mice. Through both in vivo and in vitro experiments, we demonstrate that DYRK1B promotes hepatic gluconeogenesis and glucose intolerance. Liver-specific Dyrk1b conditional knockout mice were protected ...[more]