Proteomics

Dataset Information

0

Protein interactions of a novel tRNA-derived small RNA

ABSTRACT: Explore protein binding partners of novel tRNA (tRNA-Asp-GTC-3'tDR) in HEK293 cells via IP followed by mass spectrometry.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Krystine Mansfield  

LAB HEAD: Patrick Pirrotte

PROVIDER: PXD052235 | Pride | 2025-08-08

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
005_0017_01A_R_3tDRBiotin1_24JUL20_CELL_HUM_ECL_0002_PA_75MIN_RS_RS_01.msf Msf
005_0017_01A_R_3tDRBiotin1_24JUL20_CELL_HUM_ECL_0002_PA_75MIN_RS_RS_01.pdResult Other
005_0017_01A_R_3tDRBiotin1_24JUL20_CELL_HUM_ECL_0002_PA_75MIN_RS_RS_01.raw Raw
005_0017_01A_R_3tDRBiotin2_24JUL20_CELL_HUM_ECL_0002_PA_75MIN_RS_RS_01.msf Msf
005_0017_01A_R_3tDRBiotin2_24JUL20_CELL_HUM_ECL_0002_PA_75MIN_RS_RS_01.pdResult Other
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Publications

A hypoxia-responsive tRNA-derived small RNA confers renal protection through RNA autophagy.

Li Guoping G   Sun Lingfei L   Xin Cuiyan C   Hao Tian T   Kharel Prakash P   Manning Aidan C AC   O'Connor Christopher L CL   Moore Henry H   Lei Shuwen S   Gokulnath Priyanka P   Yang Xinyu X   Sharma Ritin R   Garcia-Mansfield Krystine K   Pantham Priyadarshini P   Xiao Chunyang C   Wang Hanna Y HY   Chatterjee Emeli E   Yim Seungbin S   Ren Leo B LB   Spanos Michail M   Zhu Hua H   Li Haobo H   Lei Ji J   Markmann James F JF   Laurent Louise C LC   Rossi John J JJ   Akeju Oluwaseun O   Sheng Quanhu Q   Shah Ravi V RV   Goddard William A WA   Lowe Todd M TM   Pirrotte Patrick P   Bitzer Markus M   Ivanov Pavel P   Bonventre Joseph V JV   Das Saumya S  

Science (New York, N.Y.) 20250828 6763

Transfer RNA-derived small RNAs (tsRNAs or tDRs) perform a range of cellular functions. Here, we showed that tRNA-Asp-GTC-3'tDR, a hypoxia-induced tDR derived from the 3' end of tRNA-Asp-GTC, activated autophagic flux in kidney cells and its silencing blocked autophagic flux. Functional gain-/loss-of-function studies in murine kidney disease models demonstrated a substantial renoprotective function of tRNA-Asp-GTC-3'tDR. Mechanistically, tRNA-Asp-GTC-3'tDR assembled stable G-quadruplex structure  ...[more]

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