Dataset Information

USP10 knockout in human HCT116 cells

ABSTRACT: USP10 is an important factor in the progression of colorectal cancer, as inhibition or silencing of USP10 attenuates the aggressive phenotype. USP10 regulates sensitivity to the two widely used EGFR inhibitors gefitinib and osimertinib. Mechanistically, we show that USP10 mediates its effects via the phosphatase INPP4B, which regulates the downstream PI3K/AKT/mTOR signaling pathway. Thus, our study demonstrates for the first time a novel link between USP10 and response to EGFR-targeted therapy.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Colon Cancer

SUBMITTER: Kateryna Kubaichuk

LAB HEAD: Thomas Kietzmann

PROVIDER: PXD052294 | Pride | 2025-05-07

REPOSITORIES: Pride

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			Action	DRS
	lumos210709-10_2313-1_e5_6.raw	Raw
	lumos210709-13_2313-1_e8_1.raw	Raw
	lumos210709-14_2313-1_e8_2.raw	Raw
	lumos210709-15_2313-1_e8_3.raw	Raw
	lumos210709-16_2313-1_e8_4.raw	Raw

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Publications

Ubiquitin-specific protease 10 determines colorectal cancer outcome by modulating epidermal growth factor signaling via inositol polyphosphate-4-phosphatase type IIB.

Kubaichuk Kateryna K Seitz Timo T Bergmann Ulrich U Glumoff Virpi V Mennerich Daniela D Kietzmann Thomas T

Oncogenesis 20241011 1

Although there have been advances in understanding colorectal cancer (CRC) pathogenesis, significant gaps still exist, highlighting the need for deeper insights. Dysregulated protein homeostasis, including perturbations in the epidermal growth factor receptor (EGFR) pathway, remains a focal point in CRC pathogenesis. Within this context, the roles of ubiquitin ligases and deubiquitinases have attracted attention, but exploration of their precise contributions is still in its early stages. To add ...[more]

PMID: 39394169

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