Dataset Information

Proteome analysis in M. abscessus to study intrabacterial lipid inclusion

ABSTRACT: During infection and granuloma formation, pathogenic mycobacteria accumulate triacylglycerol in the form of Intrabacterial Lipid Inclusions (ILI). These organelles facilitate bacterial evasion from the immune system and serve as a carbon source to sustain bacterial persistence within the infected host., a rapidly-growing non-tuberculous opportunistic pathogen, was previously shown to generate similar structures throughout their infectious cycle. In this proteomics study, M. abscessus was used as a model organism to identify, at a global level, the ILI-associated proteins (IAP) involved in ILI accumulation.

INSTRUMENT(S):

ORGANISM(S): Mycobacterium Tuberculosis Mycobacterium Abscessus (strain Atcc 19977 / Dsm 44196 / Cip 104536 / Jcm 13569 / Nctc 13031 / Tmc 1543)

SUBMITTER: Luc Camoin

LAB HEAD: Luc Camoin

PROVIDER: PXD052312 | Pride | 2025-05-07

REPOSITORIES: Pride

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A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria.

Dargham Tonia T Aguilera-Correa John Jairo JJ Avellan Romain R Mallick Ivy I Celik Léa L Santucci Pierre P Brasseur Gael G Poncin Isabelle I Point Vanessa V Audebert Stéphane S Camoin Luc L Daher Wassim W Cavalier Jean-François J-F Kremer Laurent L Canaan Stéphane S

mBio 20250225 4

During infection and granuloma formation, pathogenic mycobacteria store triacylglycerol as intrabacterial lipid inclusions (ILIs). This accumulation of nutrients provides a carbon source for bacterial persistence and slows down intracellular metabolism. Mycobacterium abscessus (Mab), a rapidly growing non-tuberculous actinobacterium, produces ILI throughout its infection cycle. Here, Mab was used as a model organism to identify proteins associated with ILI accumulation on a ...[more]

PMID: 39998225

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	MSMNL_24h_Rep1_20211111191935.raw	Raw
	MSMNL_24h_Rep2.raw	Raw
	MSMNL_24h_Rep2_20211112211514.raw	Raw