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Conformational Changes in sCIMPR upon binding with IGF-2

ABSTRACT: The sCIMPR protein was incubated with IGF-2 and its binding was mapped using HRPF.

INSTRUMENT(S):

ORGANISM(S): Bos Taurus (bovine)

SUBMITTER: Sandeep Misra

LAB HEAD: Sandeep K Misra

PROVIDER: PXD052326 | Pride | 2025-05-07

REPOSITORIES: Pride

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			Action	DRS
	checksum.txt	Txt
	sCIMPR-1.raw	Raw
	sCIMPR-1.xlsx	Xlsx
	sCIMPR-2.raw	Raw
	sCIMPR-2.xlsx	Xlsx

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Publications

Lysosomal enzyme binding to the cation-independent mannose 6-phosphate receptor is regulated allosterically by insulin-like growth factor 2.

Bohnsack Richard N RN Misra Sandeep K SK Liu Jianfang J Ishihara-Aoki Mayumi M Pereckas Michaela M Aoki Kazuhiro K Ren Gang G Sharp Joshua S JS Dahms Nancy M NM

Scientific reports 20241106 1

The cation-independent mannose 6-phosphate receptor (CI-MPR) is clinically significant in the treatment of patients with lysosomal storage diseases because it functions in the biogenesis of lysosomes by transporting mannose 6-phosphate (M6P)-containing lysosomal enzymes to endosomal compartments. CI-MPR is multifunctional and modulates embryonic growth and fetal size by downregulating circulating levels of the peptide hormone insulin-like growth factor 2 (IGF2). The extracellular region of CI-MP ...[more]

PMID: 39505925

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