Bacterial pore-forming toxin pneumolysin drives pathogenicity through host extracellular vesicles released during infection

ABSTRACT: In this study, we characterized the proteomic composition of extracellular vesicles released from human THP-1 monocytes challenged with the pneumococcal pore-forming toxin, pneumolysin. We found that the vesicles shed from pneumolysin challenged cells are selectively enriched in key inflammatory host proteins relative to vesicles from untreated cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Monocyte, Cell Culture

SUBMITTER: Karthik Subramanian  

LAB HEAD: Dr Karthik Subramanian

PROVIDER: PXD052436 | Pride | 2024-07-31

REPOSITORIES: Pride