Dataset Information

Exposure of human lung bronchial epithelial cells (BEAS-2B) to urban particulate matter (PM)

ABSTRACT: Human lung cells (BEAS-2B) were exposed to either liquid suspensions of 125 ug/mL urban particulate matter (NIST, SRM 1648a) or growth media only control for 24 hours at 37C, 5% CO2. We have explored the changes in expression level and subcellular abundance of key proteins involved in cellular response to air pollution stress.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung, Epithelial Cell

SUBMITTER: Matthew Burroughs

LAB HEAD: Lydia M Contreras

PROVIDER: PXD052537 | Pride | 2026-02-10

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

Items per page:

1 - 5 of 15

Publications

Cytoplasmic localization of PUS7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance.

Ruan Minli M Engels Sean M SM Burroughs Matthew R MR Li Xiaoyan X Stower Rosella R Tzadikario Talia T Powell Connor C Bloch Dylan D Fanari Oleksandra O Akeson Stuart S Eyler Daniel E DE Weidmann Chase A CA Rouhanifard Sara S Jain Miten M Contreras Lydia M LM Koutmou Kristin S KS

bioRxiv : the preprint server for biology 20250922

Pseudouridine (Ψ) is an abundant post-transcriptional modification found across all classes of RNA. It has been widely speculated that Ψ inclusion in mRNAs might provide an avenue for cells to control gene expression post-transcriptionally. Here we demonstrate that one of the principal mRNA pseudouridylating enzymes, pseudouridine synthase 7 (PUS7), exhibits a stress-induced accumulation in the cytoplasm of yeast and human epithelial lung cells. Stress-induced and cytoplasmic localization of PUS ...[more]

PMID: 41040199

			Action	DRS
	9246_MB_01.raw	Raw
	9246_MB_02.raw	Raw
	9246_MB_03.raw	Raw
	9246_MB_04.raw	Raw
	9246_MB_05.raw	Raw

Dataset Information

Exposure of human lung bronchial epithelial cells (BEAS-2B) to urban particulate matter (PM)

Dataset's files

Publications

Cytoplasmic localization of PUS7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Similar Datasets

Integrative transcriptomic of human bronchial BEAS-2B exposed to seasonal urban PM
2016-05-26 | E-MTAB-3630 | biostudies-arrayexpress

Integrative transcriptomic profiling of human bronchial BEAS-2B exposed to seasonal urban PM
2016-05-26 | E-MTAB-3629 | biostudies-arrayexpress

mRNA-Seq of neuronal compartments with perturbed mRNA degradation machinery (overexpression of dnCaf1) in mouse primary cortical neurons
2023-07-12 | E-MTAB-12887 | biostudies-arrayexpress

mRNA-Seq of neuronal compartments in shRNA-mediated knockdown of Larp1 in mouse primary cortical neurons
2023-07-12 | E-MTAB-12886 | biostudies-arrayexpress

SlamSeq of subcellular compartments in mouse primary cortical neurons
2023-07-12 | E-MTAB-12888 | biostudies-arrayexpress

Enhancer DNA pull-down of proteins extracted from PA2 tissue of mouse E11.5 embryos
2025-04-28 | PXD063373 | Pride

lncRNA IGF1R-AS1 protein interactome in VCaP cells
2026-02-10 | PXD074272 | Pride

RNAi knock down of dU2AF50 in Drosophila mel2 cells and profiling of nuclear and cytoplasmic fractions
2007-07-05 | E-GEOD-1344 | biostudies-arrayexpress

Identification of differentially expressed genes and pathways in BEAS-2B cells upon long-term exposure to particulate matter (PM<sub>2.5</sub>) from biomass combustion using bioinformatics analysis.
| S-EPMC10519835 | biostudies-literature

Toxicological Profile of PM from Different Sources in the Bronchial Epithelial Cell Line BEAS-2B.
| S-EPMC10222988 | biostudies-literature