Proteomics

Dataset Information

0

Proteomics analysis in 1700030J22Rik-/- mouse sperm


ABSTRACT: The proteome changes were quantified in 1700030J22Rik-/- mouse sperm using Label-free by LC-MS/MS.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis, Sperm

SUBMITTER: Damin Yun  

LAB HEAD: Fei Sun

PROVIDER: PXD052721 | Pride | 2024-12-25

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
IP_IgG_1.msf Msf
IP_IgG_1.pdResult Other
IP_IgG_1.raw Raw
IP_IgG_2.raw Raw
IP_IgG_3.raw Raw
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Publications

The testis-specific gene 1700030J22Rikis essential for sperm flagellar function and male fertility in mice.

Yun Damin D   Gao Sheng S   Li Xinyao X   Shi Jie J   Wang Lingling L   Bu Tiao T   Yang Xiwen X   Wu Yunhao Y   Wu Xiaolong X   Sun Fei F  

Journal of genetics and genomics = Yi chuan xue bao 20241220 7


Spermiogenesis is an indispensable process occurring during the later stages of spermatogenesis. Despite multiple proteins being associated with spermiogenesis, the molecular mechanisms that control spermiogenesis remain poorly characterized. In this study, we show that 1700030J22Rik is exclusively expressed in testes of mice and investigate its roles in spermiogenesis using genetic and proteomic approaches. The deficiency in 1700030J22Rik in male mice results in severe subfertility, characteriz  ...[more]

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