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Timed topical dexamethasone eye drops improve mitochondrial function to suppress severe retinopathy of prematurity.

ABSTRACT: Pathological neovascularization (NV) can cause visual impairment in retinopathy of prematurity (ROP). Current treatments addressing vasoproliferative (Phase II) ROP are costly and can lead to severe complications. We show that well-timed topical 0.1% dexamethasone eye drops during early retinal neovascular formation prevents NV in five extremely preterm infants at high risk for ROP and in mouse oxygen-induced retinopathy (OIR) modeling ROP. In OIR mice, daily treatment before any NV has limited efficacy in mitigating NV, while treatment after peak NV exhibits no statistically significant effect but with a trend to exacerbating NV. Optimally timed topical dexamethasone suppression of NV in OIR is associated with increased retinal mitochondrial gene expression and a decrease in inflammatory markers predominantly expressed in immune cells. This study provides new insights into topical steroid effects in retinal NV and into mitochondrial function in phase II ROP, and suggests a simple approach to preventing severe ROP.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Retina

SUBMITTER: Zhongjie Fu

LAB HEAD: Zhongjie fu

PROVIDER: PXD052730 | Pride | 2025-05-07

REPOSITORIES: Pride

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Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.

Yagi Hitomi H Boeck Myriam M Petrishka-Lozenska Mariya M Lundgren Pia P Kasai Taku T Cagnone Gael G Neilsen Katherine K Wang Chaomei C Lee Jeff J Tomita Yohei Y Singh Sasha A SA Joyal Jean-Sébastien JS Aikawa Masanori M Negishi Kazuno K Fu Zhongjie Z Hellström Ann A Smith Lois E H LEH

Angiogenesis 20240917 4

Pathological neovascularization in retinopathy of prematurity (ROP) can cause visual impairment in preterm infants. Current ROP treatments which are not preventative and only address late neovascular ROP, are costly and can lead to severe complications. We showed that topical 0.1% dexamethasone eye drops administered prior to peak neovessel formation prevented neovascularization in five extremely preterm infants at high risk for ROP and suppressed neovascularization by 30% in mouse oxygen-induce ...[more]

PMID: 39287727

			Action	DRS
	41_HY_P17H.mzML	Mzml
	41_HY_P17H.mzid.gz	Mzid
	41_HY_P17H.pdResult	Other
	41_HY_P17H.zip	Other
	41_HY_P17H_Dexa_1.raw	Raw

Dataset Information

Timed topical dexamethasone eye drops improve mitochondrial function to suppress severe retinopathy of prematurity.

Dataset's files

Publications

Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.

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