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HUVEC Palmitoylation modification analysis

ABSTRACT: Detection of palmitoylated proteins using HUVEC cells treated with BSA or oleic acid

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Vessel Endothelium

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Yan jie Tan

LAB HEAD: Yanjie Tan

PROVIDER: PXD052827 | Pride | 2025-05-07

REPOSITORIES: Pride

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			Action	DRS
	NC_add-HA.raw	Raw
	NC_without-HA.raw	Raw
	OA_add-HA.raw	Raw
	OA_without-HA.raw	Raw
	checksum.txt	Txt

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Publications

Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice.

Tan Yanjie Y Huang Zhenzhou Z Jin Yi Y Wang Jiaying J Fan Hongjun H Liu Yangyang Y Zhang Liang L Wu Yue Y Liu Peiwei P Li Tianliang T Ran Jie J Tian He H Lam Sin Man SM Liu Min M Zhou Jun J Yang Yunfan Y

Nature communications 20240927 1

Disruption of ciliary homeostasis in vascular endothelial cells has been implicated in the development of atherosclerosis. However, the molecular basis for the regulation of endothelial cilia during atherosclerosis remains poorly understood. Herein, we provide evidence in male mice that the accumulation of lipid droplets in vascular endothelial cells induces ciliary loss and contributes to atherosclerosis. Triglyceride accumulation in vascular endothelial cells differentially affects the abundan ...[more]

PMID: 39333556

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