Proteomics

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Characterisation of reproductive tract microbiome and immune biomarkers for Bovine Genital Campylobacteriosis in vaccinated and unvaccinated heifers

ABSTRACT: Bovine genital campylobacteriosis (BGC) is a globally important venereal disease of cattle caused by Campylobacter fetus subspecies (C. fetus) venerealis. Diagnosis of BGC is highly challenging due to the lack of accurate diagnostic tests. To characterise the immune biomarkers for C. fetus venerealis infection, a total of twelve six cycling heifers were selected and categorised as vaccinated (n=6) with Vibrovax® (Zoetis™) and unvaccinated (n=6). All heifers were oestrous synchronised with a double dose of prostaglandin (PGF2) 11 days apart and when in oestrous intravaginally challenged with 2.7x109 CFU live C. fetus venerealis. Relative abundances of serum proteins were calculated using sequential window acquisition of all theoretical fragment ion spectra coupled to tandem mass spectrometry (SWATH-MS) for all heifers at three timepoints: pre-challenge, post-challenge and post-recovery.

INSTRUMENT(S):

ORGANISM(S): Bos Taurus (bovine)

TISSUE(S): Blood Serum

SUBMITTER: Ali Raza  

LAB HEAD: Ala Tabor

PROVIDER: PXD052863 | Pride | 2024-10-17

REPOSITORIES: Pride

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20220218_Ali_DDA_F1.group Other
20220218_Ali_DDA_F1.wiff Wiff
20220218_Ali_DDA_F1.wiff.scan Wiff
20220218_Ali_DDA_F2.wiff Wiff
20220218_Ali_DDA_F2.wiff.scan Wiff
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Characterisation of reproductive tract microbiome and immune biomarkers for bovine genital campylobacteriosis in vaccinated and unvaccinated heifers.

Juli Mst Sogra Banu MSB   Raza Ali A   Forutan Mehrnush M   Siddle Hannah V HV   Fordyce Geoffry G   Muller Jarud J   Boe-Hansen Gry B GB   Tabor Ala E AE  

Frontiers in microbiology 20240819

<h4>Background</h4>Bovine genital campylobacteriosis (BGC) is a globally important venereal disease of cattle caused by <i>Campylobacter fetus</i> subspecies <i>venerealis</i>. Diagnosis of BGC is highly challenging due to the lack of accurate diagnostic tests.<h4>Methods</h4>To characterise the biomarkers for <i>C. fetus venerealis</i> infection, a total of twelve cycling heifers were selected and categorised as vaccinated (<i>n</i> = 6) with Vibrovax® (Zoetis™) and unvaccinated (<i>n</i> = 6).  ...[more]

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