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Discovery and development of CLL-1 as a cellular immunotherapy target in juvenile myelomonocytic leukemia

ABSTRACT: Juvenile myelomonocytic leukemia (JMML) is an aggressive hematologic malignancy with myeloproliferative characteristics that affects young children and is associated with significant morbidity and mortality. Leukemia stem cells (LSCs) have been shown to drive relapse and progression in JMML and include Lin-CD34+CD38-/+ hematopoietic stem cells (HSCs)14. We therefore sought to develop cellular immunotherapy against JMML by employing a multi-modal omics strategy, focusing specifically on targeting chemoresistant LSCs

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood

SUBMITTER: Abhilash Barpanda

LAB HEAD: Arun Wiita, Elliot Steglitz

PROVIDER: PXD052910 | Pride | 2025-02-03

REPOSITORIES: Pride

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			Action	DRS
	2023-04-10-decoys-uniprot_hum_proteome.fasta.1.pepindex	Fasta
	230726_Wiita_ER_29_Slot1-4_1_4713.mzML	Mzml
	230726_Wiita_ER_30_Slot1-5_1_4714.mzML	Mzml
	230726_Wiita_ER_31_Slot1-6_1_4715.mzML	Mzml
	230726_Wiita_ER_A_Slot1-8_1_4717.mzML	Mzml

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