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Mimic miR-497a-5p in vivo intervention

ABSTRACT: The use of microRNA mimics to increase microRNA levels in the developing organs of newborn mice. Livers from mice treated with 100 mg/kg of an in vivo miR-497a-5p LNA mimic at postnatal day (P)1 and P3 were harvested at postnatal day (P)5. Lungs and livers from mice treated with daily 10 mg/kg intraperitoneal injections of an in vivo miR-497a-5p mimic were harvested at postnatal day 14.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung, Liver

SUBMITTER: Frank Stein

LAB HEAD: Rory Morty

PROVIDER: PXD053069 | Pride | 2026-07-13

REPOSITORIES: Pride

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			Action	DRS
	FragPipe_workflow.workflow	Other
	P2960_fractionated_ion.tsv	Tabular
	P2960_fractionated_peptide.tsv	Tabular
	P2960_fractionated_protein.tsv	Tabular
	P2960_fractionated_psm.tsv	Tabular

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1 - 5 of 19

Publications

Functional delivery of commercially-available microRNA mimics to the organs of developing mice.

Willen Sven S Myti Despoina D Obeidat Razan R Casado Francisco F Khaghani Raziabad Solmaz S Nardiello Claudio C Günther Stefan S Haberkant Per P Stein Frank F Khan Muzamil M MM Pepperkok Rainer R Rickert-Zacharias Verena V Vadász István I Herold Susanne S Hilgendorff Anne A Mižik Ivana I Seeger Werner W Morty Rory E RE

RNA (New York, N.Y.) 20260724

MicroRNA are pivotal regulators of organ and tissue homeostasis and development, and pathogenic mediators of disease. While antagonism of specific microRNA species <i>in vivo</i> is easily accomplished in experimental animal models using locked nucleic acid (LNA)-stabilized antimiRs, microRNA mimicry -that is, increasing the abundance of specific microRNA species- in experimental animals is more challenging. In this study, commercially available naked LNA-stabilized oligonucleotides designed as ...[more]

PMID: 42498504

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2026-07-19 | PXD057195 | Pride

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2022-02-17 | PXD027945 | Pride

Chemoproteomic screen to identify rabeprazole off-targets in intact HEK293 MSR cells

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2021-04-06 | PXD024294 | Pride

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