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Proteomic Vascular Anomalies detected during Migraine Surgery

ABSTRACT: BACKGROUND: Many patients with temporal or occipital migraines experience localized and throbbing pain, suggesting potential involvement of extracranial vessels. This study aimed to assess the presence or absence of vascular anomalies through proteomic analysis of biopsies. METHODS: Intraoperatively, thirty-three biopsies were collected, including 19 from the superficial temporal artery and 14 from the occipital artery, and immediately processed for proteomic analysis. RESULTS: A total of 5339 proteins were identified. Comparison of temporal arteries between younger and older patients revealed 394 significantly dysregulated proteins, with 204 upregulated in younger patients and 190 upregulated in older patients. Similarly, comparison of occipital arteries between younger and older patients revealed 325 significantly dysregulated proteins, with 91 upregulated in younger patients and 234 upregulated in older patients. CONCLUSIONS: The data collected, indicative of organic lesions, support the rationale for surgical therapy. Our results suggest differences between younger patients (showing an antiinflammatory substrate) and older patients (displaying a pro-inflammatory substrate). These findings imply that in younger patients, the local tissue response tends to counteract the inflammatory state, while in older patients, the local inflammatory state becomes chronic and selfmaintaining.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Artery

SUBMITTER: Martina Bartolucci

LAB HEAD: Andrea Petretto

PROVIDER: PXD053441 | Pride | 2026-07-16

REPOSITORIES: Pride

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			Action	DRS
	10_T_G_10.raw	Raw
	11_T_V_11.raw	Raw
	12_T_V_12.raw	Raw
	13_T_V_13.raw	Raw
	14_T_V_14.raw	Raw

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