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Influence of 4-Weeks Cranberry Juice Supplementation on Exercise-Induced Physiological Stress and Inflammation

ABSTRACT: This study examined the effect of 4-weeks unsweetened 100% cranberry juice versus placebo juice ingestion in moderating exercise-induced inflammation.

INSTRUMENT(S): Orbitrap Exploris 240

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Disease Free

SUBMITTER: Qibin Zhang

LAB HEAD: Qibin Zhang

PROVIDER: PXD053543 | Pride | 2025-05-07

REPOSITORIES: Pride

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	221110_60SPD_EV09_DIA_Quant_S01_A.raw	Raw
	221110_60SPD_EV09_DIA_Quant_S01_B.raw	Raw
	221110_60SPD_EV09_DIA_Quant_S01_C.raw	Raw
	221110_60SPD_EV09_DIA_Quant_S01_D.raw	Raw
	221110_60SPD_EV09_DIA_Quant_S01_E.raw	Raw

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Publications

A Multiomics Evaluation of the Countermeasure Influence of 4-Week Cranberry Beverage Supplementation on Exercise-Induced Changes in Innate Immunity.

Nieman David C DC Sakaguchi Camila A CA Williams James C JC Woo Jongmin J Omar Ashraf M AM Mulani Fayaj A FA Zhang Qibin Q Pathmasiri Wimal W Rushing Blake R BR McRitchie Susan S Sumner Susan J SJ Lawson Jackie J Lambirth Kevin C KC

Nutrients 20240926 19

<h4>Objectives</h4>This study examined the effect of a 4-week unsweetened cranberry beverage (CRAN) (317 mg polyphenols) versus placebo beverage (PLAC) ingestion (240 mL/day) on moderating exercise-induced changes in innate immunity.<h4>Methods</h4>Participants included 25 male and female non-elite cyclists. A randomized, placebo-controlled, double-blind crossover design was used with two 4-week supplementation periods and a 2-week washout period. Supplementation periods were followed by an inte ...[more]

PMID: 39408218

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Effects of aronia juice consumption on the mRNA expression profile in peripheral blood mononuclear cells in subjects at cardiovascular risk

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Supplementation of specific collagen peptides following high-load resistance exercise upregulates gene expression in pathways involved in skeletal muscle signal transduction

Project description:Previous evidence suggests that resistance training in combination with specific collagen peptides (CP) improves adaptive responses of the muscular apparatus. Although beneficial effects have been repeatedly demonstrated, the underlying mechanisms are not well understood. Therefore, the primary objective of the present randomized trial was to elucidate differences in gene expression pathways related to myofibrillar protein synthesis following acute high-load resistance exercise with and without CP intake. Recreationally active male participants (n=30) were equally randomized to high-load (80% one-repetition maximum) leg extension exercise in combination with 15g CP or placebo (PLA) supplementation. Muscle biopsies from the vastus lateralis muscle were obtained at baseline as well as 1h, 4h and 24h post exercise to investigate gene expression using next generation sequencing analysis. Several important anabolic pathways including PI3K-Akt and MAPK pathways were significantly upregulated at 1h and 4h post-exercise (p<0.05). Significant between-group differences for both pathways were identified at the 4h time point. Gene expression related to the mTOR pathway demonstrated a higher visual increase in the CP group compared to PLA with no statistically significant group differences. The current findings revealed a significantly higher upregulation of key anabolic pathways (PI3K-Akt, MAPK) in human skeletal muscle in response to acute resistance training combined with intake of 15 g collagen peptides compared to placebo. Further investigations are needed to examine potential long-term effects on anabolic pathways on the protein level.

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Gastritis gastric juice profile

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Physiological and molecular dissection of daily variance in exercise capacity

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