Ring study of patients suffering from focal segmental glomerulosclerosis as a proof of concept for federated proteomics.

ABSTRACT: Quantitative mass spectrometry has transformed proteomics by allowing the simultaneous quantification of thousands of proteins. To boost statistical power, it is necessary to increase sample sizes by combining patient-derived data from various institutions. However, this practice raises significant privacy concerns. We created this dataset comtaining 30 healthy donors and 30 patients suffering from focal segmental glomerulosclerosis - a rare kidney disease - and distributed them to three independent proteomics centers. This distributed data were used as a proof of concept to introduce FedProt - the first privacy-preserving tool for collaborative differential protein abundance analysis of distributed data.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Focal Segmental Glomerulosclerosis

SUBMITTER: Johannes Schmidt  

LAB HEAD: Stefan Kalkhof

PROVIDER: PXD053560 | Pride | 2024-08-08

REPOSITORIES: Pride