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Multi-center study of E.coli colonies as a proof of concept for federated proteomics.

ABSTRACT: Quantitative mass spectrometry has transformed proteomics by allowing the simultaneous quantification of thousands of proteins. To boost statistical power, it is necessary to increase sample sizes by combining patient-derived data from various institutions. However, this practice raises significant privacy concerns. We created a DIA-LFQ dataset containing 118 samples generated from Escherichia coli MG1655 (DSM 18039) cultures and distributed them to five independent proteomics centers. This distributed data were used as a proof of concept to introduce FedProt - the first privacy-preserving tool for collaborative differential protein abundance analysis of distributed data.

INSTRUMENT(S):

ORGANISM(S): Escherichia Coli

SUBMITTER: Yuliya Burankova

LAB HEAD: Prof. Dr. Jan Baumbach

PROVIDER: PXD053812 | Pride | 2025-04-29

REPOSITORIES: Pride

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			Action	DRS
	20230516_EXPL1_LiSc_SA_S610_RT_25_s2.raw	Raw
	20230516_EXPL1_LiSc_SA_S610_RT_26_s9.raw	Raw
	20230516_EXPL1_LiSc_SA_S610_RT_27_s12.raw	Raw
	20230516_EXPL1_LiSc_SA_S610_RT_28_s17.raw	Raw
	20230516_EXPL1_LiSc_SA_S610_RT_29_s24.raw	Raw

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