Dataset Information

Proteomic profiling of Pseudosulfitobacter pseudonitzschiae and Cellulophaga lytica in mono- and coculture.

ABSTRACT: This study was conducted in order to monitor the effect of coculture on the proteomes of both partners (Pseudosulfitobacter pseudonitzschiae and Cellulophaga lytica) and identify which proteins are involved in their asymmetric interactions.

INSTRUMENT(S):

ORGANISM(S): Pseudosulfitobacter Pseudonitzschiae Cellulophaga Lytica

SUBMITTER: Sjef Boeren

LAB HEAD: Sjef Boeren

PROVIDER: PXD053874 | Pride | 2025-09-08

REPOSITORIES: Pride

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Publications

Pseudosulfitobacter pseudonitzschiae hitchhikes on gliding colonies of Cellulophaga lytica.

Gavriilidou Asimenia A Murace Maria M Portoghese Marina M Schouten Sanne S Hamidjaja Raditijo R Escobar Doncel Álvaro Á Boeren Sjef S Giesbers Marcel M Capoulade Jérémie J Vignolini Silvia S Smidt Hauke H Ingham Colin J CJ

ISME communications 20250101 1

Interspecies interactions shape microbial communities; this is central for microbial ecology. Cellulophaga lytica PlyA2 is a marine flavobacterium, which glides over surfaces and forms ordered, structurally coloured colonies, which display angle-dependent reflection of light. Pseudosulfitobacter pseudonitzschiae SW is an apparently nonmotile, nonstructurally coloured marine bacterium. Here, we aim to understand the interaction of both strains at cellular, genomic, optical, and prot ...[more]

PMID: 40860567

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Project description:Activation of the maternal immune system during pregnancy can fetal development, which can lead to postnatal susceptibility to a wide range of diseases, including cardiovascular, metabolic and psychiatric disorders. During maternal immune activation (MIA), the maternal body must balance its ressources between mounting an immune response and investing resources into continued metabolism and growth : both essential for survival of the fetus and a successful pregnancy. How the placenta responds to MIA over time and how it can protect the fetus is not well understood, and neither are the fetal consequences of MIA. Here, we characterised the response to an induced acute inflammation in maternal lungs over time across maternal and fetal organs, using a combination of omics-methods, imaging and integrative computational analysis. We found that the placenta, unlike other maternal organs, did not react by inducing a typical inflammatory response, but instead initially induced genes associated to strengthen tissue integrity and simultaneously reduced growth to prevent exposure to potential infections. Afterwards, a return to homeostasis was observed, with heightened biosynthesis and expression of endoplasmic reticulum (ER) stress genes. This mechanism likely protects the fetus from inflammation, as we observed no immune response in the fetal liver transcriptome. Instead, we observed metabolic adaptations in the fetus, including a release of docosahexaenoic acid (DHA) Notably, DHA has a crucial function for fetal brain development , and levels of triglyceride and phosphatidylcholine lipids that are necessary for transportation of DHA to the brain were also increased. This metabolic response is likely a combination of the placental MIA response and temporary maternal fasting, caused by MIA-induced fever and lack of nutrient intake. Our study shows, for the first time, the temporal and systemic response to MIA in lungs across maternal and fetal organs.

			Action	DRS
	HS03_sample_P1.raw	Raw
	HS04_sample_P2.raw	Raw
	HS05_sample_P3.raw	Raw
	HS06_sample_P4.raw	Raw
	HS07_sample_S1.raw	Raw

Dataset Information

Proteomic profiling of Pseudosulfitobacter pseudonitzschiae and Cellulophaga lytica in mono- and coculture.

Dataset's files

Publications

<i>Pseudosulfitobacter pseudonitzschiae</i> hitchhikes on gliding colonies of <i>Cellulophaga lytica</i>.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Proteomic profiling of Pseudosulfitobacter pseudonitzschiae and Cellulophaga lytica in mono- and coculture.

Dataset's files

Publications

&lt;i&gt;Pseudosulfitobacter pseudonitzschiae&lt;/i&gt; hitchhikes on gliding colonies of &lt;i&gt;Cellulophaga lytica&lt;/i&gt;.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

<i>Pseudosulfitobacter pseudonitzschiae</i> hitchhikes on gliding colonies of <i>Cellulophaga lytica</i>.