Proteomics

Dataset Information

0

Glutathione Oxidation in Cerebrospinal Fluid as a Biomarker of Oxidative Stress in Amyotrophic Lateral Sclerosis [Glutathione]


ABSTRACT: We performed unbiased quantitative mass spectrometry (MS)-based analysis to measure changes in protein abundance and oxidation in cerebrospinal fluid (CSF) from a cohort of Amyotrophic Lateral Sclerosis (ALS) patients and healthy controls at two time points (approximately four months apart) to capture disease progression. In addition, we developed a sensitive and targeted quantitative MS method to measure glutathione oxidation state in the same sets of CSF samples.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebrospinal Fluid

DISEASE(S): Ftdals1

SUBMITTER: Trong Khoa Pham  

LAB HEAD: Trong Khoa Pham

PROVIDER: PXD053913 | Pride | 2025-07-14

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
GSH_Results.xlsx Xlsx
OT_211013_COEN_CSF_FTru_N01_01.raw Raw
OT_211013_COEN_CSF_FTru_N02_01.raw Raw
OT_211013_COEN_CSF_FTru_N03_01.raw Raw
OT_211013_COEN_CSF_FTru_N04_01.raw Raw
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Publications

Glutathione oxidation in cerebrospinal fluid as a biomarker of oxidative stress in amyotrophic lateral sclerosis.

Pham Trong Khoa TK   Verber Nick N   Turner Martin R MR   Malaspina Andrea A   Collins Mark Oliver MO   Mead Richard J RJ   Shaw Pamela J PJ  

Translational neurodegeneration 20250707 1


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